John M. Wetzel, Ph.D.
Wetzel Chemistry Consulting, LLC
4141 Baker Rd.
Albany, OH 45710
Phone:
(740) 698-0420
Cell: (201) 693-0031
Web Page: www.wetzelconsulting.com
Specialties:
- Medicinal Chemistry
- Organic Chemistry
- Analytical Chemistry
Chemistry Leadership and Patent Assistance:
- Staff selection and mentoring
- Compound design, synthesis and evaluation
- Infrastructure design and implementation
- Laboratories for synthesis and analysis
- Automation & sample logistics
- Information management
- Management of Chemistry, Manufacturing & Controls
- Transition to permanent leadership and facilities
- Intellectual property protection
- Assurance that clients' patents claim their technology appropriately and are free of value-jeopardizing errors
Chemistry Leadership:
Our pharmaceutical clients rapidly progress their compounds toward clinical validation while building infrastructure only as they need it and can afford it. We lead the early stage chemistry effort, helping the client advance projects, protect intellectual property, select staff and build infrastructure. Our experience and extensive network of contacts help our clients make good decisions and efficient progress while acquiring the necessary in-house expertise for long-term success.
Patent Assistance:
Our clients find that the value of their patents is ensured and their senior chemists can stay focused on making new discoveries when they use our patent writing services. These clients avoid ambiguities and writing errors, through our assistance, that could cause them to lose millions of dollars in patent value. We are detail-oriented, industry-experienced medicinal and analytical chemists with strong writing skills. We work with the inventors and their attorneys to ensure that the Company’s patents describe their inventions precisely, claim them appropriately, and are free of errors that could cost the Company millions of dollars. Our involvement frees up the time of the Company’s senior chemistry staff and provides assurance to the Management that the Company’s patents afford the desired exclusivity rights.
Laboratory Facilities:
Available as needed
Education:
Ph.D., Chemistry, The Johns Hopkins University, Baltimore, MD, 1988.
B.S., Chemistry, Ohio University, Athens, OH, 1982.
Experience:
Wetzel Chemistry Consulting, LLC
Albany, OH.
2005-present, Principal
Lundbeck Research USA
Paramus, NJ.
2003-2005, Director, Chemistry Support Services
- Led project teams for MCH1 antagonist discovery and Chemistry Technology Platform development.
- Co-led the selection of an automated storage / retrieval strategy for the Lundbeck screening collection worldwide.
Synaptic Pharmaceutical Corporation
Paramus, NJ.
1990-2003, positions of increasing responsibility, culminating in Director, Department of Chemistry
- Managed 40 FTEs, including Medicinal, Computational, Analytical and Bioanalytical Chemists.
- Managed the outsourcing of Chemistry, Manufacturing and Controls (CMC) efforts for preclinical and clinical development of a novel anti-depressant, including chemical process development, GMP-compliant synthesis, GLP-compliant analysis and bioanalysis, and formulation. Contributed CMC section to IND filing and annual update.
- Designed and synthesized alpha-1a adrenoceptor antagonists for treatment of benign prostatic hyperplasia.
- Discovered the first subtype-selective alpha-1a antagonist, SNAP 5089.
- Discovered highly selective alpha-1d adrenoceptor antagonists exemplified by SNAP 8493.
- Designed and implemented a novel strategy for the efficient characterization, purification and formatting of combinatorial libraries culminating in neat solid archive samples.
- Developed a novel LCMS-guided HPLC purification strategy for library purification.
- Conducted numerous HPLC separations, including enantioselective separations and high-throughput library purifications, on milligram and gram scales.
- Procured and maintained NMR, LCMS, HPLC and other instruments.
Suntory Institute for Bioorganic Research
Osaka, Japan
1988-1990, Postdoctoral Fellow
- Explored the chemical relationship between the brown planthopper (Nilaparvata lugens) and its intracellular yeast-like symbiote through deuterium labeling and GCMS techniques.
Patents:
Co-inventor on 15 U.S. Patents
Publications:
Co-author of 23 peer-reviewed publications
Grants:
Principal Investigator for Phase I and Phase II SBIR Grants
Technical Societies:
American Chemical Society
For detailed qualifications, please see: www.wetzelconsulting.com
