Michael J. Micklus, Ph.D
Drexel University
424 Gladstone Avenue
Haddonfield, NJ 08033-4006
Phone:
(856) 429-0968
Professional Experience:
| 2001-present: | Drexel University, Visiting Research Associate (Nanotechnology Center/Materials Engineering). Contributed to development of high modulus biodegradable electrospun nanofibers for drug delivery and tissue engineering. |
| 1997-2005 | Mach I, Consultant. Passivated zirconium powder and modified catalysts as potential rocket fuel additives. Developed and formulated carboxyl-terminated polybutadiene polymer to meet U.S. Air Force specifications for rocket-binder fuels. Contributed to development of iron nanofibers as infrared obscurant. |
| 2004-2005 | Cleo Cosmetic and Pharmaceutical Company. Synthesized derivatives of hyaluronic acid for evaluation in tissue preservation media. |
| 1996-1996 | Kelly Scientific Resources (Wyeth-Ayerst). Temporary position as a Specification Coordinator in Quality Assurance. Revised testing standards to reflect manufacturing changes in INDs and NDAs for Premarin and drugs transferred to Wyeth-Ayerst from Lederle Labs. |
| 1994-2000 | Villanova University, Adjunct Faculty, Chemistry Department. Taught general chemistry, chemistry laboratory, and biochemistry undergraduate courses. Supervised laboratory teaching assistants. |
| 1992-1993 | Wyeth-Ayerst Labs, Senior Clinical Writer. Prepared medical reports (GMRs) on clinical studies to support IND and NDA submissions. |
| 1990-1992 | National Institute on Aging, NIH, Laboratory of Neurosciences, Special Expert. Developed protein and peptide (e.g., insulin) liposomal formulations for targeting drugs to the blood-brain barrier. |
| 1988-1989 | Technology Unlimited, Inc., Project Manager. Directed development of liposomal formulations for the controlled release of bioactive materials. |
| 1984-1988 | Wyeth Laboratories, Novel Drug Delivery, Research Scientist. Researched liposomal and transdermal drug delivery systems. Supervised manufacturing of clinical supplies. |
| 1979-1984 | Extracorporeal, Senior Polymer Chemist. Improved cellulosic membranes for kidney dialysis by characterizing cuproammonium cellulose solution and recommending formulation changes. Evaluated hemocompatibility of membranes and solved manufacturing problems of kidney dialysis membranes. |
| 1976-1979 | Biosearch, Inc., Chemical Consultant. Patented hydrogel coatings for catheters and other medical devices. Developed QA procedures for biomedical adhesives and polymers, including epoxy resins for heart pacemakers. |
| 1974-1995 | University of the Pacific, School of Pharmacy, Research Fellow in Medicinal Chemistry. Synthesized novel narcotic analgetics and antagonists based on structural relationships with morphine. |
| 1971-1973 | Harvard Medical School, Associate in Organic Chemistry, and Beth Israel Hospital, Research Fellow in Medicine. Investigated uremic toxins in body fluids. Developed techniques for colorimetric determination of guanidino- and phenolic-related substances in serum and urine. |
Education:
- M.S. Materials Engineering, Drexel University, 1991.
- Ph.D. Physical Organic Chemistry, University of Miami (FL), 1971.
- B.S. Chemistry, Rutgers University, 1961
Patents:
- International Patent WO9402178 and Australian Patent AU977216, "Targeting of liposomes to the blood-brain barrier."
- US Patents 4,100,309 and 4,119,094. "Coated substrate having a low coefficient of friction. Hydrophilic coating and a method of making the same."
Publications:
- Ayutsede J, Gandhi M, Sukigara S, Micklus M, Chen H, Ko F., "Regeneration of Bombyx mori silk by electrospinning. Part 3: characterization of electrospun nonwoven mat." Polymer 46:1625-1634, 2005.
- Sachiko S, Gankhi, Ayutsede J, Micklus M, Ko F., "Regeneration of Bombyx mori silk by electrospinning. Part 2. Process optimization and empirical modeling using response surface methodology." Polymer 45:3701-3708, 2004.
- Sachiko S, Gankhi, Ayutsede J, Micklus M, Ko F., "Regeneration of Bombyx mori silk by electrospinning. Part1:processing parameters and geometric properties." Polymer 44:6721-5727, 2003.
- Micklus MJ, Greig NH, Tung J, Rapoport SI., "Targeting of liposomes to the blood-brain barrier in rats." Drug Delivery 1:21-26, 1993.
- Micklus MJ, Greig NH, Tung J, Rapoport SI., "Plasma clearance of liposomes in rats." Proceed Intern Symp Control Rel Bioact Mater 19:353-354, 1992.
- Micklus MJ, Greig NH, Tung J, Rapoport SI., "Organ distribution of liposomal formulations following intracarotid infusion in rats." Biochim Biophys Acta 1124:7-12, 1992.
- Micklus MJ. "Liposomes enhance the oral availability of certain water-insoluble drugs." Ann NY Acad Sci 618:589-591, 1991.
- Micklus MJ. "Determination of (14C)glucose diffusion from various liposomal formulations under thermodynamically stable conditions." Proceed Intern Symp Control Rel Bioact Mater 16:320-321, 1989.
Present Affilitations
- Member, Chemical Consultants Network;
- American Chemical Society;
- American Chemical Society;
- Controlled Release Society;
- Sigma Xi
