Dr. Leo S. Geraci, Ph.D.
2269 Monroe Avenue
Cincinnati, OH 45212-3121
Phone:
(513) 351-2671
E-mail: leosgeraci@gmail.com
Specialties:
- Organic Chemistry
- Chemical Synthesis and Synthetic Routes
- Chemistry R&D, Product and Process R&D
- Discovery, Medicinal and Pharmaceutical R&D
- cGMP, Regulatory Compliance
- Radiosynthesis
- Optimization, Purification
- Project Liaison
- Documentation, Technical Writing
Professional Services and Assistance Offered:
Chemistry R&D, Product and Process R&D
- Organic Chemical Synthesis and Synthetic Routes
- Asymmetric, Catalytic and Organometallic Reactions
- Project Planning, Leadership and Management
- Problem Solving and Interdisciplinary Collaboration
- Scale-up, Optimization, Process Development,cGMP, Quality Support
- Purification, Testing and Analysis, Analytical Development
- Radiochemistry
- Solid Phase Synthesis
- Library Selection, Lead Optimization, Synthesis, SAR
- Physico-Chemical Properties, Solubility, pKa, Log P/D
- Assays, Efficacy, Pharmacology Profiling
- DMPK, ADME, Toxicity
- Safety Assessment
- Literature Search, Technical Writing, Editing,
Document Review, Technical Transfer - Assistance with cGMP Compliance, Batch Records, SOPs,
OOS, Change Control, Deviation, Corrective and Preventive Actions, QA/QC, Audits - Assistance with Regulatory Documents
- Reports, Patents, Grants, Summaries, Compose, Draft
- Outsourcing Liaison, Vendor Selection, Raw Materials, Suppliers
- Multidisciplinary Collaboration
Other Assistance with:
Reducing Costs, Product Improvement, Training, Goal Setting, Chemical Safety, Waste, Spills,
Industrial and Household Chemical Products, In-House Assistance, Staffing
Professional Experience and Expertise:
Over fourteen years of organic synthesis, discovery research and chemical development experience in the chemical and pharmaceutical industry. Designed and performed multi-step syntheses of small and complex molecules, new chemical entities and pharmacologically active compounds. Supervisory, leadership and project management experience. Collaborated in a multidisciplinary environment with excellent communication skills. Competent with modern instrumentation and computer applications. Experience in a regulatory environment and FDA inspected facilities.
Senior Associate Scientist, 2006-2009
Girindus America, Inc., Member of Solvay Organics Cincinnati, OH
An FDA inspected facility offering contract pharmaceutical and small molecule R&D, production, radiosynthesis and oligonucleotide synthesis.
- Project Leader, fifteen multi-step radiochemistry and
small molecule synthesis projects, mg-kg scales - Completed seven projects compliant with cGMP
and regulatory requirements - Completed a solid phase radiosynthesis of a 13-base
oligonucleotide using a DNA/RNA synthesizer - Used original or modified client technical packages,
investigated/applied alternative strategies - Communicated extensively with clients, delivered project
updates,
reports and presentations - Collaborated with Small Molecules, Medicinal,
Oligonucleotide, QC and QA Departments - Wrote Batch Records, SOPs, OOS, Change Control,
Deviation, CAPA - Extensive interaction with vendors for sourcing of
raw materials, equipment and supplies - Complied with regulatory requirements, cGMP training,
radio, chemical and hazardous materials safety - Company first aid/CPR/AED certified responder and
Safety Officer (2008) - Used modern computer applications and instrumentation
(NMR (1-D, 2-D), MS, HPLC, UV-IR, radio liquid
scintillation, Radio TLC, DNA/RNA synthesizer)
Senior Research Scientist I, II, 1997-2005
Institute for Diabetes Discovery, LLC
Branford, CT
A drug discovery company committed to the development of novel treatments
and therapies for diabetics, complications from diabetes, obesity and related disorders.
Drug Discovery, Medicinal Chemistry
- Lead Project Chemist for second generation aldose
reductase inhibitor (ARI) program
Designed and synthesized several compounds that were
highly active (IC50 4-8 nM), selective (25,000:1),
effective (ED50 0.6 mg/kg/d) and had favorable ADMET.
Optimized selective transition metal mediated cross-coupling
reactions on dichloropyridines. Scaled synthetic routes
for animal studies. Favorable compounds were
recommended for clinical development. - Project Chemist for advanced glycation end products(AGE),
glycation inhibition and PTP1B projects - Selected compound libraries for screening, synthesized
leads, performed multi-step syntheses of analogs, applied
SAR, physico-chemical properties, analyzed assay databases
and X-ray structures - Collaborated with the Departments of Biology, High
Throughput Screening (HTS), Pharmacokinetics,
and Comparative Medicine - Participated in multidisciplinary project meetings,
prepared reports, presentations, publications, patents - Supervised chemists, provided training, leadership and
annual performance reviews, completed management training
sessions, conducted interviews - Used modern instrumentation (NMR (1-D, 2-D), MS, HPLC,
GC, UV-IR) and coordinated instrument maintenance - Utilized outside vendors for supplementary compound
analysis and in vitro and in vivo testing
SERES Laboratories, Inc.
Santa Rosa, CA
Contract chemical and pharmaceutical R&D, cGMP production
- Multi-step syntheses of targeted molecules, API s and pharmacologically active compounds, mg-kg
- Completed a 22-step synthesis of the Mycobacterium tuberculosis siderophore Exochelin
- Clinical scale quantities of a Gd-porphyrin agent for photodynamic cancer therapy
- R&D for the production of a dermatological polymer
- Communicated with clients, assisted with proposals, prepared reports and summaries
- Used modern instrumentation (NMR, HPLC, GC, UV-IR)
Postdoctoral Fellow, 1992-1994
Department of Chemistry, University of Utah
Salt Lake City, UT
Principal Investigator: Gary E. Keck, Ph.D.
Contributed to the discovery and development of the catalytic asymmetric allylation (CAA) reaction. This breakthrough accessed chiral homoallylic alcohols in high enantiomeric excess through the reaction of aldehydes with allyltri-n-butylstannane and catalytic amounts of a Lewis acid (Ti) and a chiral ligand (BINOL). This reaction is equivalent to an asymmetric aldol of acetaldehyde or acetic acid after oxidative cleavage of the vinyl functionality. Used modern instrumentation (NMR, HPLC, GC, UV-IR,
polarimetry)
Education:
B.S., Chemistry, The University of Cincinnati
Cincinnati, OH, 1985
Ph.D., Organic Chemistry, The University of Texas
Austin, TX, 1992
Dissertation Advisor: Stephen F. Martin, Ph.D.
