Raymond Cvetovich
RJC Process Chemistry Consulting LLC
329 Fawnridge Drive
Scotch Plains, NJ 07076
Phone:
(908) 285-9078
E-mail: rcvetovich@gmail.com
Specialties:
- Process Research Chemistry and Development
- Technical Transfers to CMOs
- Processing scale-up issues, problem solving, defining critical process parameters
- Managing CRO process research
- Reaction development
- Crystallization processes for API and critical intermediates
Services:
Specializing in process research expertise and practical technical advice in solving and avoiding problems in your API synthesis so that your process is both robust and scaleable
Process Research and Development
Designing, evaluating and managing synthetic route development to API and intermediates for long term and short term requirements, focusing on: costs, scalability, robustness, and safety.
- Problem solving scale-up issues
- Reaction optimization and improvement (yield, productivity, time cycles, exotherm control, kinetics, by-product formation, safety)
- Design of experiments (DoE) to evaluate and define operating conditions and critical process parameters (CPPs)
- Crystallization development of polymorphs, solvates, hydrates, and salts of API and critical intermediates
- Chiral chemistry, resolutions, racemization/resolution, dynamic resolutions, catalytic reactions
- Support of data analysis: HPLC, GC, LCMS, NMR, DSC, XRPD, TG, KF, titrations
- Flow Chemistry
Technical Transfer
- Writing and review of technical transfer and CMC documents, and patents
- Oversight and performance review of CMO operations
- Managing and review of CRO efforts for process development
- Writing and coordination of CMC chemistry and analytical sections
Contract Laboratory Work
- Available to work within your laboratories for process development or CMC issues
Training Seminars and Lectures
- Aspects of process development, critical process parameters, developing reactions and crystallizations, and solving scale-up issues
- Seminars on real world process chemistry project experiences
