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  • 03 Jul 2020 2:44 PM | Dr. Keith D. Wing (Administrator)

    Virtual Meeting of the Princeton ACS Section   http://chemists.princeton.edu/pacs/event/pacs-virtual-meeting-july-15/


    Wednesday, July 15, 2020, 11:30 AM “GoToMeeting” 

     Colin Suckling, PhD

    Research Professor of Chemistry, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland

         “Off Paradigm Drug Discovery and the AMR / COVID-19 Era”

    Abstract- For many years it had been recognized that the world was facing a problem in the lack of new anti-infective drugs to tackle the increasing prevalence of microbial resistance to existing drugs. The global pharmaceutical industry had largely ignored the problem for understandable commercial reasons. The standard industry drug-discovery paradigm of single drug, single target leading to predefined beneficial effect also imposes limitations on the discovery of resilient antimicrobial drugs because resistance can easily arise from mutations in the target (together with other mechanisms). Such target driven drug discovery is powerful but in fields such as anti-infective drugs, other approaches that I call ‘off-paradigm’ become highly relevant if they lead to resilient new drugs. This was the approach we took at Strathclyde using minor groove binders for DNA (S-MGBs) and we have been able to discover a wide range of anti-infective compounds for bacterial, fungal, and parasitic diseases, the most advanced of which has successfully completed a Phase 2a clinical trial.

     

    Then along came COVID-19 and changed the world. Interestingly and perhaps surprisingly some of our S-MGBs had shown high activity against hepatitis C virus in vitro. This raised the obvious question of whether S-MGBs would be active against COVID-19, a question that is being addressed right now. Further, the acute effects of COVID-19 infection including the so-called cytokine charge and serious lung disorders pointed to the importance of another of our off-paradigm drug discovery projects in the field of anti-inflammatory and immunomodulatory compounds. In this second project, from the starting point of a protein secreted by a parasitic nematode worm we discovered a range of compounds, known as SMAs, that have been shown to be highly effective in a wide range of animal models of disease, including some relevant to treating COVID-19 patients. This talk will discuss the design, biological activity, and mechanism of action (as much as is known) of S-MGBs and SMAs and speculate about their potential contribution to treatments for COVID-19 infections and future biosecurity.

     

    Biography - Colin Suckling is a graduate of the University of Liverpool (BSc 1967, PhD 1970, DSc 1989) and has spent most of the rest of his academic career at the University of Strathclyde where he was Freeland Professor of Chemistry from 1989 to 2012. During the 1990s until 2002, was Dean of the Faculty of Science, Deputy Principal, and Vice Principal of the University. Currently he is a Research Professor of Chemistry.

     

    Research interests focus on the synthesis and properties of heterocyclic compounds designed as molecular probes for biological systems and as drugs for treating infectious and inflammatory diseases. The most advanced compound, a DNA Minor Groove Binder (MGB), has successfully completed a phase 2a clinical trial for the treatment of Clostridium difficile infections (May 2020). Other compounds in the Strathclyde collection of MGBs are nearing candidate selection status as treatments for African Animal Trypanosomiasis and also as antifungal compounds. A further advanced project in medicinal chemistry entering the commercial phase concerns immunomodulatory compounds based upon the structures of protein secretions of parasitic worms. The small molecule analogues of the parasite protein show great promise as treatments for inflammatory diseases such as rheumatoid arthritis, asthma, and lupus.

     

    Colin has published over 250 papers and books. He was the Adrien Albert Lecturer of the Royal Society of Chemistry (2009-10), Chairman of the 2011 International Congress of Heterocyclic Chemistry held in Glasgow, recipient of the Nexxus Lifetime Achievement Award (2011), and elected an Honorary Life Fellow of the Indian Society of Chemists and Biologists (2011).  Colin is a Fellow of many learned societies and Royal Colleges including the Royal Society of Chemistry, the Royal Society of Edinburgh, the Royal College of Surgeons of Edinburgh and the Royal College of Physicians and Surgeons of Glasgow. He was a B.D Tilak Fellow of the Indian Institute of Technology, Mumbai, in 2019.

     

     

    Registration/ Join Meeting:

     

    Registration for the meeting is requested.  To do so, please go to go our website at http://chemists.princeton.edu/pacs/event/pacs-virtual-meeting-july-15/

    Please join my meeting from your computer, tablet or smartphone. 
    https://global.gotomeeting.com/join/583199957 

    You can also dial in using your phone. 
    United States: 
    +1 (224) 501-3412 

    Access Code: 583-199-957 

    New to GoToMeeting? Get the app now and be ready when your first meeting starts: 
    https://global.gotomeeting.com/install/583199957

     


  • 06 May 2020 11:32 PM | Dr. Keith D. Wing (Administrator)

    Meeting of the Princeton ACS Section (  http://chemists.princeton.edu/pacs/event/princeton-acs-may-13-online-meeting/)

    Wednesday, May 13, 2020 - “GoToMeeting”

    6:30 PM – 8:00 PM 

    6:30 PM - Dr. Niny Rao, Associate Professor of Chemistry, Thomas Jefferson University

    “Chemistry in Your Cup – Chemical Characteristics of Cold Brew Coffee”

    Abstract: Both small and large commercial coffee brewers have recently begun offering cold-brew coffee drinks to customers with claims that these cold-water extracts contain fewer bitter acids, due to brewing conditions, while still retaining the flavor profile. Dunkin Donuts’ website suggests that the cold-water and long brewing times allow the coffee to reach “... its purest form.” With very little research existent on the chemistry of cold- brew coffee, consumers are left to the marketing strategies of Starbucks and other companies regarding the contents of cold-brew coffee. Our goal is to provide some scientific information about this new coffee trend. The present research employs a simple French press style set-up to brew both cold brew and hot brew coffee. We varied the brewing time, origin of beans, and degree of roast to understand how these parameters affect the acidity, antioxidant activity, as well as the concentration of caffeine of the coffee brew.

    Biography: Dr. Niny Rao is an Associate Professor of Chemistry and the Director of Chemistry and Biochemistry Program at Thomas Jefferson University, College of Life Sciences. She received her bachelor degree in chemical engineering from the Cooper Union and went on to pursuit a PhD in physical chemistry at Florida State University. A computational chemist by training, her past research interests spanned from small inorganic ion clusters to protein-lipid bilayer complex. As an enthusiast of artisanal food and beverages, Dr. Rao has expanded her research into the field of food science, such as chemistry of cold brew coffee.

    7:00PM - Dr. William K. HallmanProfessor & Chair of the Department of Human Ecology, Rutgers University

     “Communicating about Science, Risk, and Health in an Era of Virally Disseminated Nonsense”

    Abstract: Most of our lifelong learning about science occurs informally, outside of a classroom, and often on the Internet. In this presentation, I will use examples drawn from food, health, and the environment to talk about virally disseminated misinformation, how to communicate with others about science, and why presenting scientific facts alone typically isn’t enough to persuade people to change their minds or their behaviors.

    Biography: Dr. William K. Hallman is a Professor and the Chair of the Department of Human Ecology at Rutgers University and is a Distinguished Research Fellow at the Annenberg Public Policy Center of the University of Pennsylvania. An experimental psychologist with expertise in science and risk communication, he has written extensively about numerous issues concerning health, food, technology, and the environment. These include studies of public perception, communication, and behavior change strategies involving infectious and non-communicable diseases, unexplained symptom syndromes, food safety and food insecurity, preventive health behaviors, environmental contaminants, climate adaptation and mitigation, responses to natural and technological disasters, and new food technologies including genetic modification, gene editing, nanotechnology, animal cloning, and the development of cell-based meats and seafood.

    Dr. Hallman has served as the Director of the Rutgers Food Policy Institute and as Chair of the FDA’s Risk Communication Advisory Committee. He currently serves as a member of several committees of the National Academies of Science, Engineering, and Medicine, including the Advisory Committee for the Academies’ Climate Communications Initiative and the Standing Committee on Advancing Science Communication Research and Practice. He authored the Climate Communications Initiative Strategic Plan, as well as the National Academies’ consensus report: Communicating Science Effectively, A Research Agenda, which has been downloaded more than 32,000 times. He also coauthored the Risk Communication Applied to Food Safety Handbook, published jointly by the FAO and WHO.

    Registration for the meeting is requested.  To do so, please go to http://chemists.princeton.edu/pacs/event/princeton-acs-may-13-online-meeting/

    Please join my meeting from your computer, tablet or smartphone.  https://global.gotomeeting.com/join/583199957 

    You can also dial in using your phone.  United States: +1 (224) 501-3412 

    Access Code: 583-199-957 

    New to GoToMeeting? Get the app now and be ready when your first meeting starts: 
    https://global.gotomeeting.com/install/583199957


  • 25 Feb 2020 2:11 PM | Dr. Keith D. Wing (Administrator)

    Wednesday, March 11, 2020

    Professor Gene Hall

    Department of Chemistry & Chemical Biology, Rutgers University

    “From Electronic Cigarette Liquids to Sushi: Molecular Characterization Using Multiple Different Mass Spectrometers”

    Frick Chemistry Laboratory, Princeton University

    Lecture in Auditorium at 6:00 pm, followed by dinner in Atrium

    Join us at our “Sushi & Snacks” pre-talk Mixer at 5:15 pm in the Atrium to network with colleagues!!

     

    Abstract

    I am delighted to share with you the use of several analytical tools in my mass spectrometry toolbox to characterize a variety of consumer products.  Some of the products discussed are used by the general population spanning from high school students to senior citizens. 

    Consumers are faced with a daunting task trying to decipher fact from fiction when purchasing products to improve health and longevity.  To assist consumers, we have been using several different types of mass spectrometers that include GC-TOF-MS, linear ion traps, Q-TOF, IMS-Q-TOF, and LDI-TOF-TOF to characterize all types of samples from electronic cigarette liquids to sushi.  Our philosophy for analyses centers around minimal or no-sample preparation and taking an untargeted approach in our workflows. This presentation will then focus on basic mass spectrometry that is used to determine purity, molecular structure, concentrations, and sources of a variety of consumer products that the audience uses daily. Also presented will be a forensic approach to solving an actual adulterated dietary supplement product sold as a health fraud product targeted towards senior citizens.

    Biography 

    Professor Gene S. Hall received his BS degree in both Chemistry and Mathematics in 1973 from Tusculum College and his PhD in radiochemistry from the Virginia Polytechnical Institute (Virginia Tech) in 1978.  He then went on to the Department of Chemistry and Chemical Biology at Rutgers University in 1979 as an assistant professor of analytical chemistry to fulfill his life-long dream of


    being a chemistry professor.  He is currently full professor where his focus is on using state-of-the-art mass spectrometry to characterize various consumer products such as dietary supplements, natural foods, artist paintings, and electronic cigarettes.

    Registration

    The meeting will be held in Frick Laboratory, Princeton University. The social mixer and dinner will be in the CaFe area of the atrium and the lecture in the auditorium (B02).  Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd. Visitor parking is available all day in Lot 21, corner of Faculty and Fitzrandolph Roads, or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/).  Registration is required for this meeting. The seminar is free and open to the public.  Dinner is $25 ($10 for students) and $22.50 if prepaid with credit card (select "pay by debit or credit card").  To register and prepay go to our website at http://chemists.princeton.edu/pacs/event/princeton-acs-meeting-wednesday-march-11/. If you have questions, contact louise.lawter@gmail.com.  Please make your dinner reservations by March 9, 2020.



  • 29 Jan 2020 1:31 PM | Dr. Keith D. Wing (Administrator)

    Meeting of the Princeton ACS Section.  http://chemists.princeton.edu/pacs/event/february-12-meeting-of-the-princeton-acs/

    Wednesday, February 12, 2020

     Lisa Veliath, PhD - Senior Research Investigator, International Flavors & Fragrances 

    “Terpene Chemistry in the Fragrance Industry”

    Ron Gabbard, PhD - Director, Delivery Systems, International Flavors & Fragrances 

    Takashi Sasaki, PhD - Senior Research Investigator, International Flavors & Fragrances 

     “Fragrance Delivery”

    Frick Chemistry Laboratory, Princeton University; Mixer 5:30 pm; Lecture 6:00 pm followed by dinner

     

    Abstract: Terpenes are fundamental building blocks for fragrance ingredients. Presented will be some insight into IFF as a leader in the fragrance industry, what it’s like to work as a synthetic chemist in Fragrance Ingredient R&D, and some classic chemistry that is conducted on a multi-ton scale to supply the consumer demand for aroma chemicals. Examples of odor categories will be demonstrated on blotters. 

     

    Incorporation of fragrances into delivery systems designed for specific applications and shelf-life requirements will be discussed. Examples will be demonstrated.

     

    Biographies: Lisa Veliath is currently a Senior Research Investigator for Fragrance Ingredient Synthesis at IFF. She received her BS in Chemistry/Nutrition from Fordham University and her PhD in Organic Chemistry from Rutgers University under Dr. Roger Jones. Her professional career has spanned several areas of industry, including pharmaceuticals (Merck), agrochemical analytical research (Eurofins) and consumer products (Kraftfoods). She has been at IFF for 7 years.

     

    Ronald Gabbard is the Director for Delivery Systems at IFF.  His team focuses on the encapsulation and controlled release of flavors and fragrances in a wide range of applications.  Dr. Gabbard received his BS, MS, and PhD, all in chemical engineering from New Jersey Institute of Technology where he is also an accessional adjunct faculty member and is also on the Chemical and Material Engineering Department’s Industrial Advisory Board.

     

    Takashi Sasaki is a Senior Research Investigator for Delivery Systems at IFF. His research focuses on fragrance encapsulation technologies in various consumer product application. He received his BS with University Honors in Chemistry from Carnegie Mellon University and his PhD from Rice University in Organic Chemistry and Material Science under Professor James M. Tour. Before joining IFF, Takashi completed his post-doctoral fellowship at Rijksuniversiteit Groningen in the Netherlands under Professor Ben Feringa.

     

    Reservations: The meeting will be held in Frick Laboratory, Princeton University. The social mixer and dinner will be in the CaFe area of the atrium and the lecture in room A57. Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd. Parking is available in Lot 21, corner of Faculty and Fitzrandolph Roads or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/.  Registration is required for this meeting. The seminar is free and open to the public.  Dinner is $25 ($10 for students) and $22.50 if prepaid with credit card (select "pay by debit or credit card").  Our website link for reservations and prepayment will be active shortly at http://chemists.princeton.edu/pacs/event/february-12-meeting-of-the-princeton-acs/. If you have questions, contact louise.lawter@gmail.com.  Dinner registration deadline is February 9, 2020.


  • 07 Nov 2019 8:11 AM | Dr. Keith D. Wing (Administrator)

    6th Annual Holiday Joint Social with Philadelphia Area Great Careers Group, ChemPharma, BENG, Greater Philadelphia Veterans Network, Bucks County Marketing & WordPress Consortium, and Nonprofit Career Networking Philly at Bonefish Grill, 160 N. Gulph Rd., King of Prussia, PA. (to the left of Primark)


    1. Cash bar so you purchase your own beverages

    2. Register and pay $10 for hors d’oeuvres by Thanksgiving or $15 thereafter on events calendar at chempharma.net

    3. Sign up on the attendance list at http://bit.ly/2019SocialRSVP 

    4. Check out who is coming:http://bit.ly/2019SocialKOP

    5. Questions? Contact Lynne Williams 610-405-9756 or director@greatcareersphl.org or message through LinkedIn at www.linkedin.com/in/lynnewilliams 




    ChemPharma-SocialS.PNG


  • 24 Oct 2019 9:17 PM | Dr. Keith D. Wing (Administrator)

    This event is free and should be very interesting.  Details and registration at link 

    https://singhnano.eventbrite.com

  • 16 Oct 2019 4:16 PM | Dr. Keith D. Wing (Administrator)

    Meeting of the Princeton ACS Section & US Section of the Royal Society of Chemistry

    Wednesday, November 6, 2019 

    Les McQuire, PhD
    Global Program Team Director, Novartis

    "Pharma Drug Discovery & Development: Insights from a Career in Both"

     Frick Chemistry Laboratory, Princeton University; Mixer 5:30 pm; Lecture 6:30 pm followed by dinner

     

    Abstract
    The process to discover, develop and launch a single new drug typically requires large teams working in multiple related but very different fields over a period of many years. Drawing extensively from the presenter’s own diverse experiences this talk will review the overall drug discovery and development process, indicating where and how it has and continues to evolve and particularly highlight the types of decisions that are made along the way and how they can influence the options at and outcomes of the later steps.

    Biography
    Les McQuire received his BSc and PhD in Chemistry from Dundee University, his home town in Scotland, and then moved to the University of Texas at Austin to conduct post-doctoral research in natural product synthesis. Following this, he joined Ciba Pharmaceuticals, now Novartis, in Summit NJ in the Medicinal Chemistry Research Department. Les eventually moved to the Novartis location in Cambridge, MA to help build the research organization there. At various times he has focused on Arthritis, Inflammation, Immunology or Cardiovascular programs, across all stages of the discovery process.
    After 18 years in Research Les moved into Program Management in the Novartis Oncology Development and moved back to NJ. For almost all of the last 9 years Les has worked on novel treatments for breast cancer including Kisqali and the recently launched Piqray.  As part of the core team overseeing Novartis’s breast cancer franchise Les was involved in all aspects of the Development process from clinical Proof of Concept in patients, through the design and implementation of clinical trial programs, compound manufacture, data analysis, submission and Health Authority approval and ultimately global launch. Les recently moved between areas in oncology and now serves as Global Program Executive Director for a portion of Novartis’s large Hematology franchise. 
    Les is actively involved in scientific societies serving as councilor for the North Jersey ACS Section, in various other local and national ACS roles and as a member of the Executive Committee and a Past-President of the US Section of the Royal Society of Chemistry (RSC.)

    Reservations

    The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of the atrium (Taylor Commons.) The lecture will be held in the Auditorium (B02) at 6:30 pm followed by dinner in Taylor Commons (CaFe area).  Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/.) Reservations are required for the meeting. The seminar is free and open to the public.  Dinner is $10 for students and $25 for adults ($22.50 if prepaid using PayPal).


    To register and prepay go to our website at  http://chemists.princeton.edu/pacs/event/princeton-acs-november-6-meeting/ If you have questions, contact louise.lawter@gmail.com”. 


  • 08 Jul 2019 9:19 PM | Dr. Keith D. Wing (Administrator)

    July 30 PACS Science CAFÉ ( http://chemists.princeton.edu/pacs/event/princeton-acs-july-30-science-cafe)


    A Matter of Taste: Forces Driving our Eating Preferences and Patterns


    Our panel of nutrition, food science and culinary arts experts will enlighten us and spark brainstorming and satiating discussion of this important topic. After all, we are what we eat...and should know why we eat what we eat.

    When: Tuesday, July 30, 2019

    5:30 – 5:45 pm            Welcome/Sign-in

    5:45 – 8:30 pm            Light meal buffet

    Fun Quiz, Expert/Audience Discussion

    Where: Frick Laboratory, Princeton University

    Cost: $15 includes light nutritious meal buffet  if prepaid  ($10/student)

    Panelists:
    Professor Beverly Tepper, PhD - Rutgers University, IFT Fellow
    Professor Karen Schaich, PhD – Rutgers University, IFT Fellow
    Brenda Burgess, PhD – Nutrition Scientist, Elmhurst Milked Direct
    Craig Shelton – CEO, Aeon Holistic Agriculture, Princeton University Instructor, Chef and Culinary Expert
     
    Who Should Attend?
    Scientists and Non-Scientists; Educators and Students; Bright Future Enthusiasts

    Reservations
    Reservations are required.  To register go to 
    http://chemists.princeton.edu/pacs/event/princeton-acs-july-30-science-cafe/. Cost, which includes meal buffet is $15 if prepaid ($10/students) and $18 at the door ($12/student). Space will be limited. (questions? weintraubr@gmail.com).


    The meeting will be held in Frick Laboratory, Princeton University, Room A057. Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium. Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane after 5:00 pm. (see http://m.princeton.edu/map/.)

    Event Coordinators: Randy Weintraub, MS, PhD and Barbara Ameer, PharmD, MBA



  • 08 Jul 2019 12:40 PM | Michael P. Bigwood, Ph.D.

    Dear Fellow Chemical Consultant

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    Polymer Phases has a chemical laboratory. Located in Oklahoma City, OK, the lab has the following capabilities:

    General organic synthesis to 1 L

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                  Radical and condensation polymerization processes

                  Emulsion, suspension, solution and bulk polymerizations

    Formulations up to five gallons

    pH, viscosity, optical microscopy (400X), moisture content

    Let’s partner! Together, we can do things that we cannot do individually. You provide your specific chemical expertise, and I provide my 50 years of hands-on laboratory experience. Please feel free to call me if you want more information about the laboratory’s capabilities or if you want to discuss a specific project.

    Hoping to hear from you,

    Mike

    Michael P. Bigwood, PhD

    Polymer Phases, Inc.

    6060 Monte Vista Ln. # 1123, Fort Forth, TX 76132

    215 514 2006     mpbigwood@polymerphases.com


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