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Dr. Ron Bihovsky

Key Synthesis LLC

 

Member profile details

Photo
First name
Dr. Ron
Last name
Bihovsky
Organization
Key Synthesis LLC
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Contact information

City
Wynnewood
State or Province
Pennsylvania
Zip Code
19096
Country
United States
Phone
610-357-3281
 

Specialties and Services

Fields of Expertise
  • Biotechnology
  • Expert Witness
  • Literature and Patent Searches
  • Medicinal Chemistry
  • Organic Chemistry
  • Patents
  • Pharmaceutical
  • Research and Development
  • Synthesis
Other Fields of Expertise
Organic / Medicinal Chemistry Consultant with Laboratory
Expert Witness, Testifying Experience
Organic Synthesis
Custom Synthesis
Medicinal Chemistry
Pharmaceutical Chemistry
Biotechnology - Small Molecules
Organic Chemistry Consulting
Research and Development
Summary
Organic chemistry and medicinal chemistry expert with fully equipped laboratory. Custom organic synthesis, consultant, expert witness.
Services
- Custom synthesis for the pharmaceutical and biotechnology industries
- Authentic samples of biologically active compounds
- Key intermediates and building blocks
- Analog synthesis - Lead optimization
- Biotechnology - Small molecules
- Synthesis of metabolites
- Intellectual property
- Litigation support
- Process research

Dr. Ron Bihovsky is the founder of Key Synthesis LLC, an organic chemistry laboratory located in the Philadelphia, Pennsylvania metropolitan area. Key Synthesis is fully equipped to conduct custom organic synthesis, contract medicinal chemistry research and process research for the pharmaceutical and biotechnology industries. www.keysynthesis.com

Dr. Ron Bihovsky performs chemical research and consults for the pharmaceutical and biotechnology industries. He has served as an organic chemistry and medicinal chemistry consultant and expert witness in over eighty Hatch-Waxman pharmaceutical patent litigation cases involving patent validity and generic drugs. He has been deposed and has testified at high-profile pharmaceutical patent litigation trials with favorable outcomes.

Dr. Bihovsky, an organic, pharmaceutical and medicinal chemist, has more than 30 years of experience in the pharmaceutical industry, where he worked on numerous classes of small molecules including heterocycles, enzyme inhibitors and peptide mimetics. Before working in industry, Dr. Bihovsky conducted research on total synthesis of natural products as a professor of organic chemistry at Stony Brook University. He has taught graduate courses in medicinal chemistry and organic synthesis. He has authored over 50 publications and is an inventor on 17 US patents and numerous international patents. He serves on the steering committee of Chemical Consultants Network, and was previously its chairman and its treasurer.

Dr. Bihovsky earned a Ph.D. in organic chemistry from the University of California, Berkeley, and was an NIH postdoctoral fellow at the University of Wisconsin, Madison.
 

Additional Information

Education
Ph.D. in organic chemistry from the University of California, Berkeley
NIH postdoctoral fellow at the University of Wisconsin, Madison
Patents
A. Fleischman, J. Parvizi, and R. Bihovsky, “Compositions and Methods for Determining the Presence of Active Leukocyte Cells Using an Electrochemical Assay” WO 2020069176; US 11,104,933 (2021).

S. Patil, R. Bihovsky, S. Smith, Y. Ji, V. Stella, D. Long, and D. Marquess, “Prodrugs of Fencamfamine” WO 2017048720 (2017); US Patent 10,662,146 (2020); US 2019/023650; US 2020/0399203.

K. A. Josef, J. P. Mallamo, and R. Bihovsky, "Hydroxamate-Containing Cysteine and Serine Protease Inhibitors" US Patent 7,060,683 (2006), WO 185686 (2001), EP 1754707 (2007).

M. Ator, R. Bihovsky, S. Chatterjee, D. Dunn, and R. Hudkins, "Multicyclic Compounds and the use thereof as Inhibitors of PARP, VEGFR2 and MLK3 Enzymes." WO 01/85686 (2001), EP 1294725. (2003), US Patent 7,122,679 (2006).

S. Chatterjee, J. P. Mallamo, R. Bihovsky, and G. Wells, "Peptide-Containing a Ketoamide Cysteine and Serine Protease Inhibitors" US Patent 7,001,907 (2006).

S. Chatterjee, J. P. Mallamo, R. Bihovsky, and G. Wells, "Peptide-Containing a Ketoamide Cysteine and Serine Protease Inhibitors" US Patent 6,703,368 (2004).

K. A. Josef, J. P. Mallamo, and R. Bihovsky, "Hydroxamate-Containing Cysteine and Serine Protease Inhibitors" WO 00/16767 (2001), EP 1115390 (2004), US Patent 6,686,335 (2004).


M. Tao and R. Bihovsky, "Peptidyl-2-Amino-1-hydroxyalkanesulfonic Acid Cysteine Protease Inhibitors" WO 98/47523 (1998); US Patent 6,348,448 (2002).

M. Tao and R. Bihovsky, "Peptidyl-2-Amino-1-hydroxyalkanesulfonic Acid Cysteine Protease Inhibitors" US Patent 6,500,802 (2002).

S. Chatterjee, J. P. Mallamo, R. Bihovsky, and G. Wells, "Peptide-Containing a Ketoamide Cysteine and Serine Protease Inhibitors" US Patent 6,288,231 (2001).

S. Chatterjee, J. P. Mallamo, R. Bihovsky, and G. Wells, "Peptide-Containing a Ketoamide Cysteine and Serine Protease Inhibitors" WO 99/17790 (1999); US Patent 6,150,378 (2000).

R. Bihovsky, G. Wells, and M. Tao, "Benzothiazo and Related Heterocyclic Group-Containing Cysteine and Serine Protease Inhibitors," WO 98/21186 (1998); US Patent 5,952,328 (1999).

J. P. Mallamo, R. Bihovsky, M. Tao, and G. Wells, "Phosphorous-Containing Cysteine and Serine Protease Inhibitors," WO 97/03679 (1997); US Patent 5,639,732 (1997).

J. P. Mallamo, R. Bihovsky, S. Chatterjee, and R. Tripathy, "Cysteine Protease and Serine Protease Inhibitors,"US Patent 5,658,906 (1997).

J. P. Mallamo, R. Bihovsky, S. Chatterjee, and R. Tripathy, "Cysteine Protease and Serine Protease Inhibitors," WO 96/14067 (1996); US Patent 5,498,616 (1996).

R. Bihovsky, P. Erhardt, J. Lampe, R. Mohan, and K. Shaw, "Inhibitors of the Conversion of Big Endothelin to Endothelin," WO 93/11154 (1993); US Patent 5,504,070 (1996).

H. Bates and S. Rosenblum, "Improved Synthesis of Biotin," U.S. Patent 4,656,289 (1987).
Publications
(Note: Ron Bihovsky previously worked and published under the names Ron Bates and Hans A. Bates)

S. Patil,* R. Bihovsky, S. Smith, W. Potter, V. Stella, Novel Prodrug PRX-P4-003, Selectively Activated by Gut Enzymes, May Reduce the Risk of Iatrogenic Addiction and Abuse.” Drug and Alcohol Dependence 186, 159-166 (2018).

M. Tao,* C. H. Park, R. Bihovsky, G. J. Wells, J. Husten, M. A. Ator, R. L. Hudkins, "Synthesis and Structure-Activity Relationships of Novel Poly(ADP-ribose)Polymerase-1 Inhibitors." Bioorg. Med. Chem. Lett. 16, 938-942 (2006).

G. W. Wells,* R. Bihovsky, R. L. Hudkins, M. A. Ator, and J. Husten, "Synthesis and Structure-Activity Relationships of Novel Pyrrolocarbazole Lactam Analogs as Potent and Cell-Permeable Inhibitors of Poly(ADP-ribose)polymerase-1 (PARP-1)." Bioorg. Med. Chem. Lett. 16, 1151-1155 (2006)

R. Bihovsky, M. Tao, J. P. Mallamo, and G. Wells,* "1,2-Benzothiazine 1,1-Dioxide α-Ketoamide Analogues as Potent Calpain I Inhibitors." Bioorg. Med. Chem. Lett. 14, 1035-1038 (2004).

S. J. Miknyoczki, S. Jones-Bolin, S. Pritchard, K. Hunter, H. Zhao, W. Wan, M. Ator, R. Bihovsky, R. Hudkins, S. Chatterjee, A. Klein-Szanto, C. Dionne, and B. Ruggeri, "Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor." Mol. Cancer Ther. 2, 371-382 (2003).

G. J. Wells, M. Tao, K. A. Josef, and R. Bihovsky,* "1,2-Benzothiazine 1,1-dioxide P2- P3 Peptide Mimetic Aldehyde Calpain I Inhibitors." J. Med. Chem. 44, 3488-3503 (2001).

K. A. Josef,* F. W. Kauer, and R. Bihovsky, "Potent a-Ketohydroxamate Inhibitors of Recombinant Human Calpain I." Bioorg. Med. Chem. Lett. 11, 2615-2617 (2001).

S. Chatterjee,* D. Dunn, M. Tao, G. Wells, Z.-Q. Gu, R. Bihovsky, M. A. Ator, R. Siman, and J. P. Mallamo, "P2-Achiral, P'-Extended a-Ketoamide Inhibitors of Calpain." Bioorg. Med. Chem. Lett. 9, 2371-2374 (1999).

G. J. Wells* and R. Bihovsky, "Calpain Inhibitors as Potential Treatment for Stroke and Other Neurodegenerative Diseases. Recent Trends and Developments." Expert Opin. Ther. Patents 8, 1707-1727 (1998).

M. Tao,* R. Bihovsky, G. J. Wells, and J. P. Mallamo, "Novel Peptidyl Phosphorous Derivatives as Inhibitors of Human Calpain I." J. Med. Chem. 41, 3912-3916 (1998).

S. Chatterjee,* Z.-Q. Gu, D. Dunn, M. Tao, K. Josef, R. Tripathy, R. Bihovsky, S. E. Senadhi, T. M. O'Kane, B. A. McKenna, S. Mallya, M. A. Ator, D. Bozyczko-Coyne, R. Siman, and J. P. Mallamo, "D-Amino Acid Containing High Affinity Inhibitors of Recombinant Human Calpain I." J. Med. Chem. 41, 2663-2666 (1998).

S. Chatterjee,* M. A. Ator, D. Bozyczko-Coyne, K. Josef, G. Wells, R. Tripathy, M. Iqbal, R. Bihovsky, S. Mallya, S. E. Senadhi, T. M. O'Kane, B. A. McKenna, R. Siman, and J. P. Mallamo, "Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I." J. Med. Chem. 40, 3820-3828 (1997).
More Publications
R. Bihovsky* and M. A. Ator, "Calpains: Their Role in Pathology, and New Therapeutic Opportunities." Investigational Drugs Weekly Highlights, 22-25, May, 1997.

M. Iqbal, P. Messina, B. Freed, M. Das, S. Chatterjee, R. Tripathy, M. Tao, K. A. Josef, B. Dembofsky, D. Dunn, E. Griffith, R. Siman, S. E. Senadhi, W. Biazzo, D. Bozyczko-Coyne, S. L. Meyer, M. A. Ator, and R. Bihovsky*, "Subsite Requirements for Peptide Aldehyde Inhibitors of human Calpain I." Bioorg. Med. Chem. Lett., 7, 539-544 (1997).

M. Tao*, R. Bihovsky, and J. C. Kauer "Inhibition of Calpain by Peptidyl Heterocycles." Bioorg. Med. Chem. Lett., 6, 3009-3012 (1996).

R. Bihovsky*, and I. Pendrak, "Synthesis of Cystamidin A (Pyrrole-3-propanamide), a Reported Calpain Inhibitor." Bioorg. Med. Chem. Lett., 6, 1541-1542 (1996).

S. Chatterjee*, K. Josef, G. Wells, M. Iqbal, R. Bihovsky, J. P. Mallamo, M. Ator, D. Bozyczko-Coyne, S. Mallya, S. Senadhi, and R. Siman "Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I." Bioorg. Med. Chem. Lett., 6, 1237-1240 (1996).

S. L. Meyer*, D. Bozyczko-Coyne, S. K. Mallya, C. M. Spais, R. Bihovsky, J. K. Kawooya, D. M. Lang, R. W. Scott, and R. Siman "Biologically Active Monomeric and Heterodimeric Recombinant Human Calpain I Produced Using the Baculovirus Expression System". Biochem. J. 314, 511-519 (1996).

R. Bihovsky*, B. Levinson, R. Loewi, P. W. Erhardt, and M. Polokoff, "Hydroxamic Acids as Potent inhibitors of Endothelin Converting Enzyme," J. Med. Chem. 38, 2119-2129 (1995).

R. Bihovsky*, J. C. Powers, C.-M. Kam, R. Walton, and R. Loewi, "Further Evidence for the Importance of Free Carboxylate in Epoxysuccinate Inhibitors of Thiol Proteases," J. Enzyme Inhib. 7, 15-25 (1993).

R. Bihovsky*, "Reactions of a,ß-Epoxy Carbonyl Compounds with Methanethiolate: Regioselectivity and Rate,"J. Org. Chem., 57, 1029-1031 (1992).

R. Bihovsky*, "Applications of Cyclic a-Haloethers and Unsaturated Oxonium Ions to Natural Product Synthesis: Carbon-Carbon Bond Formation," Trends in Organic Chemistry, 3, 1-6 (1992).

R. Mohan*, Y. L. Chou, R. Bihovsky, W. C. Lumma, Jr. P. Erhardt, and K. Shaw, "Synthesis and Biological Activity of Angiotensin II Analogs Containing a Val-His Replacement, ValY[CH(CONH2)NH]His," J. Med. Chem., 34, 2402-2410, (1991).

S. Rosenblum and R. Bihovsky*, "Synthesis of the Papulacandin C-Arylglucosylspiroketal Nucleus," J. Amer. Chem. Soc., 112, 2746-2748 (1990).

R. Bihovsky* and V. Bodepudi, "Synthesis of (+)-Biotin: Efficient Resolution of Key Intermediates," Tetrahedron, 46, 7667-7676, (1990).

R. Bihovsky*, M. U. Kumar, S. Ding, and A. Goyal, "Oxonium Ions in Organic Synthesis: Condensation of 2,3-Dihydrofuran and 3,4-Dihydro-2H-pyran with 1,3-Dicarbonyl Compounds," J. Org. Chem., 54, 4291-4293 (1989).

R. Bihovsky*, C. Selick, and I. Giusti, "Synthesis of C-Glucosides by Reactions of Glucosyl Halides with Oranocuprates," J. Org. Chem., 53, 4026-4031 (1988).
Miscellaneous
H. Bates*, K. Bagheri, and P. Vertino, "Effect of pH on the Regioselectivity of Pictet‑Spengler Reactions of 3‑Hydroxyphenethylamines with Formaldehyde and Acetaldehyde," J. Org. Chem. 51, 3061-3063 (1986).

H. Bates*, J. Farina, and M. Tong, "An Approach to Pseudomonic Acids from Acetylenic Precursors: Synthesis of 2‑(Hydroxymethyl)‑3‑butyn‑1‑ol," J. Org. Chem., 51, 2637-2641 (1986).

H. Bates* and S. Rosenblum, "Nucleophilic Displacements on an a‑Chlorothioether by Organocuprates: A Novel Synthesis of Desoxybiotin," J. Org. Chem., 51, 3447-3451 (1986).

H. Bates, "Structure of Crown Gall Tumor Metabolites: Chemical Mediators of Parasitism," Anal. New York Acad. Sci., 471, 289-290 (1986).

H. Bates*, N. Condulis, and N. Stein, "Reduction of Cyclic Ureas with Lithium Aluminum Hydride," J. Org. Chem., 51, 2228-2229 (1986).

H. Bates*, J. Magrath, and A. Kaushal, "A Direct Method for Assignment of Absolute Configurations in Crown Gall Metabolites: The Structure of Nopaline," J. Nat. Prod., 48, 598-601 (1985).

H. Bates* and J. Farina, "Oxonium Ion Electrophiles: Synthesis of the Hypotensive Oudenone," J. Org. Chem., 50, 3843-3845 (1985).

H. Bates* and S. Rosenblum, "300 MHz1H NMR Spectra and Conformations of Biotin and Related Hexahydrothienoimidazolone Derivatives," Tetrahedron Lett., 41, 2331-2336 (1985).

H. Bates*, L. Smilowitz, and S. Rosenblum, "A Practical Stereospecific Synthesis of the Biotin Precursor (3aa,6aa)‑1,3‑Dibenzylhexahydro‑1 H‑thieno[3,4‑d]imidazol‑2(3H)‑one 1,1‑Dioxide," J. Chem. Soc., Chem. Commun., 353-354 (1985).

H. Bates* and C. Selick, "Convenient Preparation of 2,3,4,6‑Tetra‑O‑Methyl‑ a‑D‑Glucopyranosyl Bromide," J. Carbohydr. Chem., 4, 273-275 (1985).

H. Bates*, L. Smilowitz, and J. Lin, "Preparation of (3aa,6a a)‑1,3‑Dibenzylhexahydro-1H-thieno[3,4‑d]imidazol‑2(3H)‑one: A Key Biotin Intermediate," J. Org. Chem., 50, 899-901 (1985).

H. Bates* and J. Garelick, "Synthesis of Tetrahydro‑4,6,7‑Isoquinolinetriols and Tetrahydro-4,7,8-isoquinolinetriols," J. Org. Chem., 49, 4552-4557 (1984).

H. Bates*, A. Kaushal, P. Deng, and D. Sciaky, "Structure and Synthesis of Histopine, a Histidine Derivative Produced by Crown Gall Tumors," Biochemistry, 23, 3287-3290 (1984).

H. Bates* and P. Deng, "Synthesis of the Civet Constituent cis‑(6‑Methyltetrahydropyran-2-yl)acetic Acid," J. Org. Chem., 48, 4479-4481 (1983).

H. Bates, "Characterization of Tetrahydroisoquinolines Produced by Pictet‑Spengler Reactions of Norepinephrine with Formaldehyde and Acetaldehyde," J. Org. Chem., 48, 1932-1934 (1983).

H. Bates, "Decarbonylation of Tetrahydrofuran‑2‑carboxylic Acids and Tetrahydropyran-2-carboxylic Acids in Concentrated Sulfuric Acid: Formation of Oxonium Ions," J. Am. Chem. Soc., 104, 2490-2493 (1982).

H. Bates*, "Pictet‑Spengler Reactions of Epinephrine with Formaldehyde," J. Org. Chem., 46, 4931-4935 (1981).

Continued
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